Pin1 as a marker for abnormal cell growth

Details Pin1 as a marker for abnormal cell growth Pin1 as a marker for abnormal cell growth

G - Physics

01

N

G01N 33/574 (2006.01)

Patent

CA 2392917

Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating the efficacy of a treatment of an abnormal cell growth, such as cancer, by monitoring the levels of Pin1. In another embodiment, the method includes evaluating the extent of metastasis of abnormal cell growth, such as cancer. The levels of Pin1 can be protein levels or nucleic acid levels.

L'invention concerne une méthode d'utilisation de Pin1 comme marqueur de croissance cellulaire anormale. Selon un premier mode de réalisation, cette méthode consiste à détecter un niveau de Pin1 indicateur du stade de croissance cellulaire anormale (cancer du sein ou de la prostate). Selon un deuxième mode de réalisation, ladite méthode consiste à évaluer l'efficacité du traitement de la croissance cellulaire anormale (cancer) par surveillance des niveaux de Pin1. Selon un troisième mode de réalisation, la méthode consiste à évaluer l'extension des métastases de croissance cellulaire anormale (cancer). Les niveaux de Pin1 peuvent être des niveaux de protéine ou d'acide nucléique.

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