C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2437784
This invention provides methods for diagnosing prostate cancer, methods for measuring the aggressiveness of prostate cancer, and methods for identifying prostage cancer likely to metastasize. The diagnostic and prognostic assays of this invention include methods involving the antibody-based detection of Pin1 and the amplification of Pin1 RNA. The diagnostic and prognostic assays of this invention may be used in combination with other methods of prostate cancer diagnosis including the PSA test, digital rectal exam, and Gleason prostate tumor grading system.
L'invention concerne des méthodes de diagnostic du cancer de la prostate, des méthodes de mesure de l'agressivité du cancer de la prostate, des méthodes d'identification d'un cancer de la prostate susceptible de former des métastases. Les dosages diagnostiques et pronostiques selon l'invention comprennent des méthodes consistant en une détection fondée sur un anticorps de Pin1 et en une amplification de l'ARN de Pin1. Les dosages diagnostiques et pronostiques selon l'invention peuvent être utilisés en combinaison avec d'autres méthodes de diagnostic du cancer de la prostate, notamment le test PSA, un examen rectal numérique et le système d'échelle de tumeur prostatique de Gleason.
Bao Lere
Wang Da Gong
Borden Ladner Gervais Llp
Pintex Pharmaceuticals Inc.
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