Pin1 as marker for abnormal cell growth

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2437807

Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating the efficacy of a treatment of an abnormal cell growth, such as cancer, by monitoring the levels of Pin1. In another embodiment, the method includes evaluating the extent of metastasis of abnormal cell growth, such as cancer. The levels of Pin1 can be protein levels or nucleic acid levels.

La présente invention concerne des techniques d'utilisation de protéines ou d'acides nucléiques Pin1 sous forme de marqueur de croissance cellulaire anormale. Dans un mode de réalisation de l'invention, cette technique consiste à détecter un niveau de Pin1 de façon à déterminer le stade d'une croissance cellulaire anormale, telle que celle constatée dans un cancer du sein ou de la prostate. Dans un autre mode de réalisation de l'invention, cette technique consiste à évaluer l'efficacité d'un traitement de croissance cellulaire anormale, telle que celle constatée dans un cancer, par la surveillance des niveaux de Pin1. Dans encore un autre mode de réalisation de l'invention, cette technique consiste à évaluer l'étendue des métastases de cette croissance cellulaire anormale, telle que celle constatée dans un cancer. Les niveaux de Pin1 peuvent être des niveaux de protéines ou des niveaux d'acides nucléiques.

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