Pipecolic acid-containing peptolides, their preparation and...

Details Pipecolic acid-containing peptolides, their preparation and... Pipecolic acid-containing peptolides, their preparation and...

C - Chemistry, Metallurgy

12

N

530/11.02, 195/1

C12N 1/14 (2006.01) A61K 38/12 (2006.01) C07K 7/64 (2006.01) C07K 11/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340447

Pipecolic acid-containing peptolides wherein the peptidic backbone is of at least 9 .alpha.-amino acid residues joined together by peptide bonds, particularly the compounds of formula I (see fig I) wherein the substituents have various significances, are disclosed. They can be prepared by isolation or derivation from an appropriate microorganism strain such as S 42508/F (NRRL 15761). They have interesting pharmacological, e.g. antifungal, chemotherapeutic drug resistance reversing and to some extent immunosuppressant and antiinflammatory properties.

612370

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