Piperazides of substituted phenylalanine derivates as...

Details Piperazides of substituted phenylalanine derivates as... Piperazides of substituted phenylalanine derivates as...

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 295/185 (2006.01) C07D 311/70 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01)

Patent

CA 2133761

- 42 - ABSTRACT The present invention relates to D,L-, L- and D-phe- nylalanine piperazides of formula (I) defined in claim 1 that inhibit blood coagulation, and thrombin and/or trypsin, respectively. The compounds are extraordinarily absorbable after oral, intraduodenal and in particular rectal adminis- tration and show only a low toxicity.

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