Piperazine, [1,4]diazepane, [1,4]diazocane, and...

Details Piperazine, [1,4]diazepane, [1,4]diazocane, and... Piperazine, [1,4]diazepane, [1,4]diazocane, and...

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/551 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07D 471/22 (2006.01)

Patent

CA 2552101

Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds (i.e., imidazoquinolines, tetrahydroimidazoquinolines, imidazonaphthyridines, tetrahydroimidazonaphthyridines, and imidazopyridines), pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

La présente invention a trait à des composés de cycles accolés imidazo de pipérazine, [1,4]diazépane, [1,4]diazocane, et [1,5]diazocane (c'est à dire, des imidazoquinoléines, tétrahydroimidazoquinoléines, imidazonaphtyridines, tétrahydroimidazonaphtyridines, et imidazopyridines), des compositions pharmaceutiques contenant les composés, des intermédiaires, des procédés de fabrication, et des procédés d'utilisation de ces composés en tant qu'immunomodulateurs, pour l'induction ou l'inhibition de la biosynthèse des cytokines chez des animaux ou dans le traitement de maladies comprenant des maladies virales et néoplasiques.

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