Piperazine based cytofectins

Details Piperazine based cytofectins Piperazine based cytofectins

C - Chemistry, Metallurgy

07

D

C07D 295/08 (2006.01) C07D 295/088 (2006.01) C07D 295/12 (2006.01) C07D 295/13 (2006.01) C07D 295/18 (2006.01) C07D 295/215 (2006.01)

Patent

CA 2266781

The present invention relates to piperazine based amphilic cationic lipids useful for gene therapy, transfection, and introducing immunogenic compounds for the purpose of vaccination. The disclosed compounds have lipophilic moieties linked to the ring nitrogens. In addition, at least one of the ring nitrogens is quatranized and linked to a hydrocarbon having at least one heteroatom.

L'invention a pour objet des lipides cationiques amphiphiles à base de pipérazine, qui sont utilisés dans des thérapies génétiques et des transfections et qui servent à introduire des composés immunogènes à des fins de vaccination. Lesdits composés ont des fragments lipophiles liés aux nitrogènes cycliques. En outre, l'un au moins des nitrogènes cycliques est quatranisé et lié à un hydrocarbure ayant au moins un hétéroatome.

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