Piperazine compounds used in therapy

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 241/04 (2006.01) A61K 31/495 (2006.01) A61K 31/675 (2006.01) C07D 213/75 (2006.01) C07D 295/155 (2006.01) C07F 9/6509 (2006.01)

Patent

CA 2168432

Diarylmethyl piperazine compounds are disclosed having utility as exogenous receptor combinant species for binding with receptors such as delta, mu sigma, and/or kappa receptors. Compounds of the invention may be employed as conjugates in agonist/antagonist pairs for transductional monitoring and assays of neurotransmitter function, and also variously exhibit therapeutic utility, including mediating analgesia, and possessing utility for the treatment of diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depression, asthma, emphysema, and apnea, cognitive disorders, and gastrointestinal disorders.

On décrit des composés à base de pipérazine de diarylméthyle servant d'espèces combinées pour récepteurs exogènes, destinées à se combiner avec des récepteurs tels que delta, mu, sigma et/ou kappa. On peut employer les composés inventés comme produits de conjugaison dans des couples agonistes/antagnoistes pour des surveillances transductionnelles et des titrages liés à la fonction de neurotransmission. Ils présentent aussi différentes utilités thérapeutiques, y compris dans la médiation de l'analgésie, et servent dans le traitement de la diarrhée, de l'incontinence urinaire, des troubles mentaux, des dépendances et des surdoses liées aux stupéfiants et à l'alcool, de l'oedème pulmonaire, de la dépression, de l'asthme, de l'emphysème, des apnées et des troubes cognitifs et gastro-intestinaux.

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