Piperazine derivative and processes for preparing the same

Details Piperazine derivative and processes for preparing the same Piperazine derivative and processes for preparing the same

C - Chemistry, Metallurgy

07

D

260/267.2, 260/2

C07D 295/04 (2006.01) C07D 207/404 (2006.01) C07D 295/092 (2006.01) C07D 309/12 (2006.01)

Patent

CA 1202973

PIPERAZINE DERIVATIVE AND PROCESSES FOR PREPARING THE SAME ABSTRACT The invention relates to a piperazine derivative of the formula: Image (I) wherein R1 is hydrogen, alkyl (C1-8), alkyl (C1-4)- sulfonyl or an acyl group of the formula: R CO- (wherein R3 is hydrogen, alkyl (C1-7), halogenoalkyl (C1-4), alkoxy (C1-4)- carbonyl-alkyl (C1-4), cyclalkyl (C3-6), alkenyl (C2-5)- alkoxy (C1-4), amino, alkyl (C1-4)-amino or anilino), R2 is hydrogen, alkyl (C1-4), alkoxy (C1 4)-carbonyl-alkyl (C1-4), carboxy-alkyl (C1-4), alkenyl (C2-5) or alkyl (C1-4)- sulfonyl, or R1 and R2 are combined together to form succinyl group, Ring A is phenyl, alkyl (C1-4)-phenyl or halogenophenyl, and n is an integer of 2 to 6, or a pharma- ceutically acceptable acid addition salt thereof. The piperazine derivative (I) has an intracranial pressure- lowering activity, and also has a depressing effect on central nervous system.

371038

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