Piperazine derivatives

Details Piperazine derivatives Piperazine derivatives

C - Chemistry, Metallurgy

07

D

260/267.1

C07D 241/04 (2006.01) C07D 241/08 (2006.01)

Patent

CA 1094560

ABSTRACT OF THE DISCLOSURE Piperazine compounds of the formula Image and pharmaceutically acceptable acid addition salts thereof are disclosed wherein R1 is diphenylmethyl or diphenylmethyl wherein a hydrogen atom in the phenyl groups thereof may be replaced by fluorine; R2 is hydrogen or alkyl having 1 - 5 carbon atoms and R3 and R4 are hydrogen or alkyl having 1 - 4 carbon atoms, but wherein at least one of R3 and R4 is hydrogen when R1 is diphenylmethyl. These compounds are useful for the treatment of vascular and cardiac diseases. Methods for making the compounds and pharmaceutical compositions containing the compounds are also disclosed.

271087

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