Piperazine derivatives

Details Piperazine derivatives Piperazine derivatives

C - Chemistry, Metallurgy

07

D

260/246, 260/266

C07D 295/14 (2006.01) C07D 207/24 (2006.01) C07D 209/18 (2006.01) C07D 295/088 (2006.01) C07D 295/13 (2006.01) C07D 295/15 (2006.01) C07D 295/185 (2006.01) C07D 403/00 (2006.01) C07D 413/00 (2006.01)

Patent

CA 1202627

ABSTRACT OF THE DISCLOSURE A piperazine derivative represented by the following formula: Image wherein R1: an indolyl group which may optionally be sub- stituted by one or more lower alkyl and/or lower alkoxy groups, naphthyl group which may optionally be saturated partially with 2 or 4 hydrogen atoms, or phenyl or cyclohexyl group which may optionally be substituted by one or more lower alkyl groups; A: a single bond or alkylene group; P: a single bond or vinylene group; Q: an -O-alkylene group or -NH-alkylene group when P is a single bond, or a single bond when P is a vinylene group; and R2: a lower alkyl, morpholino-lower alkyl, morpholino- carbonyl lower alkyl, piperidinocarbonyl lower alkyl, piperazinocarbonyl lower alkyl or lower alkylaminocarbonyl lower alkyl group, or an acid addition salt thereof is a proteolytic enzyme inhibitor.

404488

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