Piperazine derivatives

Details Piperazine derivatives Piperazine derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/00 (2006.01) C07D 207/27 (2006.01) C07D 207/325 (2006.01) C07D 207/335 (2006.01) C07D 209/16 (2006.01) C07D 209/46 (2006.01) C07D 211/90 (2006.01) C07D 213/30 (2006.01) C07D 213/50 (2006.01) C07D 231/56 (2006.01) C07D 295/04 (2006.01) C07D 295/096 (2006.01) C07D 295/112 (2006.01) C07D 295/135 (2006.01) C07D 295/185 (2006.01) C07D 333/20 (2006.01) C07D 401/00 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/00 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2123548

A compound represented by formula (I): (see formula I) wherein Q represents an aryl group, a heterocyclic group, a diarylmethyl group, an aralkyl group composed of an aryl group and an alkylene group, an alkyl group or a cycloalkyl group, in which the aryl group, heterocyclic group, and the aryl moiety of the diarylmethyl group and aralkyl group may be substituted with one or more substituents; R represents a bicyclic, substituted, nitrogen-containing heterocyclic group or a substituted phenyl group, in which the nitrogen- containing heterocyclic group is composed of a 5-membered, substituted, aromatic or saturated ring containing one or two nitrogen atoms and a 6-membered ring; and Z represents an alkylene group, an alkenylene group, an alkylene group, a carbonyl group, an alkylene group containing a carbonyl group or an oxalyl group, or a salt thereof. The compound has calmodulin inhibitory activity and is useful as a treating agent for diseases in the circulatory organs or in the cerebral region which are caused by excessive activation of calmodulin.

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