C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 213/56 (2006.01) C07D 215/12 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07D 401/06 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 409/14 (2006.01) C07D 413/06 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2053705
Piperazine derivative of formula (see formula I) and the pharmaceutically acceptable acid addition salts, where A is an alkylene chain of 1 or 2 carbon atoms optionally substituted by one or more lower alkyl groups; m is 0, 1 or 2, R is hydrogen or lower alkyl, R1 is aryl or a mono o.r bicyclic heteroaryl radical, R2 is hydrogen or lower alkyl, R3 is a heteroaryl radical, R4 is hydrogen, lower alkyl or aryl, and R5 is hydrogen, lower alkyl, cycloalkyl, cycloalkyl(lower)alkyl; aryl, or aryl(lower)alkyl or R4 and R5 together with the nitrogen atom to which they are both attached represent a saturated heterocyclic ring which may contain a further hetero atom are 5-HT1A- binding agents and may be used, for example, as anxiolytics.
Cliffe Ian Anthony
Warrellow Graham John
John Wyeth & Brother Limited
Ridout & Maybee Llp
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