Piperazine derivatives and process for the preparation thereof

Details Piperazine derivatives and process for the preparation thereof Piperazine derivatives and process for the preparation thereof

C - Chemistry, Metallurgy

07

D

167/222, 260/263

C07D 401/14 (2006.01) A61K 31/505 (2006.01) C07D 401/12 (2006.01)

Patent

CA 1300141

PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF A b s t r a c t the invention relates to a new and improved process for the preparation of 8-{4- [ 4-(2-pyrimidinyl)- -l-piperazinyl]-butyl}-8-aza-spiro[ 4.5]decane-7,9- -dione of the Formula I Image (I) and pharmaceutically acceptable acid addition salts thereof, which comprises hydrogenating a compound of the general Formula II Image (II) (wherein A stands for -C?C- or -CH=CH-) and, if desired, converting the compound of the Formula I thus obtained into a pharmaceutically acceptable acid addition salt thereof. The compound of the Formula I is a known anxioselective agent. The invention also relates to inter- mediates used in the above process and a method for the preparation thereof.

559846

Affiliated with

Also associated with

Rating

Piperazine derivatives and process for the preparation thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Piperazine derivatives and process for the preparation thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Piperazine derivatives and process for the preparation thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1263708