Piperazine derivatives as 5-ht receptors antagonists

Details Piperazine derivatives as 5-ht receptors antagonists Piperazine derivatives as 5-ht receptors antagonists

C - Chemistry, Metallurgy

07

D

C07D 295/13 (2006.01) A61K 31/495 (2006.01) C07D 241/04 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2125182

2125182 9314076 PCTABS00024 Compounds of formula (I) where A is an alkylene chain of 2 to 5 carbon atoms optionally substituted by one or more lower alkyl groups, R represents hydrogen or one or two same or different lower alkyl groups, R1 is a monocyclic aryl or heteroaryl radical, R2 is a mono or bicycle aryl radical and R3 is cycloalkyl and the pharmaceutically acceptable acid addition salts are novel. They are 5-HT1A-antagonists which may be used, for example, in treating anxiety.

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