Piperazine derivatives as circulation-enhancing substances

Details Piperazine derivatives as circulation-enhancing substances Piperazine derivatives as circulation-enhancing substances

C - Chemistry, Metallurgy

07

D

260/267.2, 260/2

C07D 405/10 (2006.01) C07D 295/08 (2006.01) C07D 295/096 (2006.01) C07D 317/66 (2006.01)

Patent

CA 1153377

ABSTRACT OF THE DISCLOSURE Novel N-(trimethoxybenzyl)-piperazines of the formula: Image (I), wherein A = Image , wherein R is trifluoromethyl, hydroxy, nitro, halogen, lower-alkyl, or lower-alkoxy; R' is hydrogen, trifluoromethyl, halogen, lower-alkyl, or lower-alkoxy; R" is hydrogen or lower-alkoxy, or wherein R and either R' or R" together stand for lower- alkylene dioxy, and acid addition salts thereof, a method of preparing same, pharmaceutical compositions thereof, and a method of enhancing circulation, especially cerebrovascular circulation, therewith, are disclosed.

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