Piperazine derivatives inhibiting human immunodeficiency...

Details Piperazine derivatives inhibiting human immunodeficiency... Piperazine derivatives inhibiting human immunodeficiency...

C - Chemistry, Metallurgy

07

D

C07D 241/04 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2337059

The invention concerns the use of a piperazine derivative of formula (I) wherein: A and B = C=O, C=S or CR¿7?R¿8? with R¿7? = H, methyl, cyano, cyanomethyl, CO¿2?CH¿3? or (C=O)CH¿3?, and R¿8? = H or phenyl; R¿1? to R¿6? = H, OH, or C¿1?-C¿5? alkoxy; X represents: either C=O, O(C=O), O(C=S), O(SO¿2?), NH(C=O), NH(C=S), NH(SO¿2?), S(C=O) or S(C=S), then Y=NR¿9?R¿10?, CR¿9?R¿10?R¿11? = H, C¿1?-C¿5? alkyl, C¿2?-C¿5? alkenyl or C¿2?-C¿5? alkynyl or nitrogenous heterocycle comprising 5 to 10 atoms; or O, S, O(C=O)O, NH(C=O)O, or S(C=O)O, then Y = CR¿9?R¿10?R¿11? with R¿9?, R¿10?, R¿11? as above; or one of its pharmaceutically acceptable salts for preparing a medicine inhibiting HIV. The invention is useful for treating HIV infection.

L'invention se rapporte à l'utilisation d'un dérivé de la pipérazine de formule (I), avec: A et B = C=O, C=S ou CR7R8 avec R7 = H, méthyle, cyano, cyanométhyle, CO2CH3 ou (C=O)CH3, et R8 = H ou phényle; R1 à R6 = H, OH ou alkoxy en C1 à C5; X représente: soit C=O, O(C=O), O(C=S), O(SO2), NH(C=O), NH(C=S), NH(SO2), S(C=O) ou S(C=S), alors Y = NR9R10, CR9R10R11 = H, alkyle en C1 à C5, alcényle en C2 à C5 ou alcynyle en C2 à C5 ou hétérocycle azoté comprenant 5 à 10 atomes; soit O, S, O(C=O)O, NH(C=O)O ou S(C=O)O, alors Y = CR9R10R11 avec R9, R10, R11 comme précédemment; ou l'un des ses sels pharmaceutiquement acceptables, pour la préparation d'un médicament pour inhiber la réplication du VIH. Application: traitement de l'infection par le VIH.

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