Piperazine derivatives of theophylline

Details Piperazine derivatives of theophylline Piperazine derivatives of theophylline

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 473/06 (2006.01) A61K 31/52 (2006.01) C07D 473/08 (2006.01)

Patent

CA 1223876

22520-FF ABSTRACT OF THE DISCLOSURE New compounds of the formula Image (I) and the pharmaceutically acceptable acid addition salts thereof, wherein M is selected from the group consisting of hydrogen, morpholino, benzylamino, di-n-lower alkyl amino, n-lower alkyl amino, and :aryl piperazino; Z1 and Z2 are each independently selected from the group consisting of CH2, CHOB and C=O, wherein B is selected from the group consisting of hydrogen and alkanoyl; Y is oxygen or sulfur; n is an integer from 0-4 but cannot be zero when Z1 is CHOB; m is an integer from 0-4 but cannot be zero when Z2 is CHOB; R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, trifluoromethyl, alkyl or alkoxy; and R4 and R5 are each independently lower alkyl, with the proviso that both R4 and R5 cannot be methyl when M is hydrogen; are antihistamines and are therefore useful in the treatment of respiratory diseases including asthma, hay fever, allergies and the common cold. They are also vasodilators and can be used for prevention and/or treatment of myocardial infarction.

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