Piperazine derivatives, processes for production thereof,...

Details Piperazine derivatives, processes for production thereof,... Piperazine derivatives, processes for production thereof,...

C - Chemistry, Metallurgy

07

D

167/223, 260/267

C07D 295/10 (2006.01) A61K 31/495 (2006.01) C07D 295/096 (2006.01)

Patent

CA 1248110

Abstract of the Disclosure: A l-benzyl-4-benzhydrylpiperazine derivative represented by the following general formula (I) Image ... (I) wherein R1 represents a hydrogen atom or a methoxy group, and R2 represents a hydrogen or fluorine atom, or a pharmaceutically acceptable acid addition salt there- of. The l-benzyl-4-benzhydrylpiperazine derivative or an acid addition salt thereof is prepared by reductively condensing a benzaldehyde derivative with a fluorobenz- hydrylpiperazine, or condensing a benzyl halide derivative with a fluorobenzhydrylpiperazine optionally in the pre- sence of an acid acceptor, or condensing a benzylpiperazine with a fluorobenzhydryl halide derivative and, optionally converting the product to its acid addition salt. The l-benzyl-4-benzhydrylpiperazine derivative is useful for improving a cerebrovascular disease.

477468

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