Piperazine urea derivatives as melanocortin-4 receptor agonists

Details Piperazine urea derivatives as melanocortin-4 receptor agonists Piperazine urea derivatives as melanocortin-4 receptor agonists

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/453 (2006.01) A61K 31/4545 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2498272

Certain novel piperazine urea derivatives are agonists of the human melanocortin-4 receptor (MC-4R) and, in particular, are receptor-subtype selective agonists of MC-4R. They are useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity and diabetes.

Certains nouveaux dérivés d'urée de pipérazine sont des agonistes des récepteurs humains de mélanocortine-4 (MC-4R) et notamment des agonistes de MC-4R sélectifs en fonction du sous-type. Ils sont utiles dans le traitement, la régulation ou la prévention des troubles et maladies réagissant à l'activation de MC-4R, notamment de l'obésité et du diabète.

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