C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/246, 260/266
C07D 295/20 (2006.01) C07D 211/46 (2006.01) C07D 243/08 (2006.01) C07D 295/215 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01)
Patent
CA 1258453
ABSTRACT The present invention concerns novel compounds of the formula Image (I) wherein R1 is selected from hydrogen, halogen; or trifluoro- methyl; X is oxygen or sulfur; R2 and R3 are the same or different and selected from hydrogen or lower alkyl; m is 2 or 3; Y is oxygen or sulfur; Z is selected from: -NR4R5 Image wherein R4 and R5 are the same or different and selected from hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, hydroxy-alkyl, alkoxyalkyl or alkanoyloxyalkyl, phenyl or phenyl-alkyl, wherein the phenyl groups may be unsubstituted or monosubstituted with halogen or CF3; n is 0, 1, 2 or 3; R6 and R7 are the same or different and selected from hydrogen, lower alkyl, hydroxy, lower alkoxy or lower alkanoyloxy; p is 2 or 3; R8 and R9 are the same or different and selected from hydrogen or lower alkyl; R10 is hydrogen, lower alkyl or lower alkanoyl; the term alkyl is meant to include straight and branched, saturated and unsaturated hydrocarbon groups; the term cycloalkyl is meant to include cyclic, saturated and un- saturated hydrocarbon groups; the term alkoxy is meant to include straight and branched, saturated or unsaturated alkoxy groups and the term alkanoyloxy is meant to include straight and branched, saturated and unsaturated alkanoyloxy groups; and the pharmaceutically active salts thereof. The new compounds can be used for treating mental disorders.
501267
Abramo Aina L.
Christensson Erik G.
Fex Tomas
Olsson Knut G.
Aktiebolaget Leo
Biovitrum Ab
Gowling Lafleur Henderson Llp
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