Piperazines derivatives, processes for production thereof,...

Details Piperazines derivatives, processes for production thereof,... Piperazines derivatives, processes for production thereof,...

C - Chemistry, Metallurgy

07

D

167/223, 260/267

C07D 295/08 (2006.01) A61K 31/495 (2006.01) C07D 295/096 (2006.01)

Patent

CA 1255313

67566-961 Abstract A 1-benzhydryl-4-cinnamylpiperazine derivative represented by the following Formula (I) Image (I) wherein R1 represents a hydrogen atom or a methoxy group, and R2 represents a hydrogen or fluorine atom, or a pharmaceutically acceptable acid addition salt thereof. The compound (I) is prepared by selectively reducing the corresponding 1-benzhydryl-4-cinnamoylpiperazine derivative and optionally converting the product into its acid addition salt. The compound (I) is useful for improvement of cerebrovascula disease in a human.

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