Piperazino derivatives as neurokinin antagonists

Details Piperazino derivatives as neurokinin antagonists Piperazino derivatives as neurokinin antagonists

C - Chemistry, Metallurgy

07

D

C07D 211/58 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 241/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/06 (2006.01) C07D 409/14 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 451/04 (2006.01) C07D 451/14 (2006.01) C07D 453/02 (2006.01) C07D 471/08 (2006.01) C07D 487/04 (2006.01) C07D 487

Patent

CA 2228370

The invention relates to compounds of formula (I) wherein Z, Rc, y, m, u, Ar2, n, X, Rc',(I) and Ar2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

Composés de formule (I), dans laquelle Z, R¿c?, y, m, u, Ar¿2?, n, X, R¿c'?, (I) et Ar¿2? sont conformes aux spécifications du dossier. Ces composés sont des antagonistes de la neurokinine, utiles au traitement de maladies chroniques des voies respiratoires telles que l'asthme.

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