Piperazinyl-and piperidinyl-cyclohexanols

Details Piperazinyl-and piperidinyl-cyclohexanols Piperazinyl-and piperidinyl-cyclohexanols

C - Chemistry, Metallurgy

07

D

C07D 405/08 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07C 45/59 (2006.01) C07C 49/747 (2006.01) C07D 211/14 (2006.01) C07D 211/18 (2006.01) C07D 211/22 (2006.01) C07D 295/096 (2006.01) C07D 317/54 (2006.01) C07D 319/18 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2083913

Novel piperazinyl- and piperidinyl-cyclohexanols of the formula: (see formula I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are independently selected from H, halogen, CF3 or C1-4 alkoxy groups except that R1 and R2 cannot both be H simultaneously, and R1 and R2, when on adjacent carbon atoms, can be taken together to form a (see formula II) bridge with n being an integer from 1 to 3; R3 is H or C1-4 alkyl; R4 and R5 are each independently selected from H, C1-4 alkyl or phenyl; Y is N or CH; and Ar is a heteroaryl, an unsubstituted phenyl ring, or a substituted phenyl ring of the formula: (see formula III) wherein X and X' may be halogen, nitro, amino, carboxamido, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 alkylthio or X and X' can be taken together to form a (see formula IV) bridge (n=1-3) are useful as anxiolytic agents and have other psycho-tropic properties.

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