C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/223, 260/266
C07D 401/04 (2006.01) A61K 31/495 (2006.01) C07D 213/74 (2006.01) C07D 403/04 (2006.01)
Patent
CA 1303042
Abstract 9387-93 A compound of the formula:- Image (I) or a pharmaceutically acceptable salt thareof, wherein "Het" is selected from (a) a 3- or 4-pyridinyl group optionally substituted by one or two substituents each independently selected from C1-C4 alkyl and amino, (b) a 2-pyridinyl group substituted by an amino group, (c) a 2-imidazolyl group optionally substituted by one or two C1-C4 alkyl groups and (d) a 2-, 3- or 4-pyridinyl group substituted by a nitro group, or an N-oxide thereof, or a 2-, 3- or 4-pyridinyl group substituted by a group of the formula -NHCOO(C1-C4 alkyl); R is selected from (a) -NHSO2R3 where R3 is C1-C4 alkyl, C3-C7 cycloalkyl or -NR1R2 where R1 and R2 are each independently H or C1-C4 alkyl, (b) -SO2NR1R2 where R1 and R2 are as defined above, (c) nitro, (d) amino and (e) acetamido; and X is a group of the formula -(CH2)m- where m is an integer of from 1 to 4, -CO(CH2)n- or -CH(OH)(CH2)n- where n is 1, 2 or 3. Apart from the compounds in which "Het" is as defined in part (d) above, which are synthetic intermediates, the compounds are all useful as cardiac antiarrhythmic agents. PLC 424
529034
Cross Peter E.
Dickinson Roger P.
Cross Peter E.
Dickinson Roger P.
Limited Pfizer
Smart & Biggar
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