C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/245
C07D 401/14 (2006.01) A61K 31/50 (2006.01) C07D 237/22 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2004298
Abstract The invention relates to new piperazinylalkyl- 3(2H)-pyridazinones of the formula Image I in which the radicals R1 represents hydrogen, phenyl, benzyl, or (C1-C6)-alkyl which is unsubstituted or substituted one or more times by hydroxyl, piperidine, morpholine or by a group NR4R5 in which R4 and R5 can be identical or different and which represent hydrogen, methyl or ethyl, R2 and R3 represent hydrogen, halogen, (C1-C4)-alkoxy or (C1-C6)-alkyl, where at least one of the radicals R2 or R3 denotes hydrogen, R6 represents hydrogen, (C1-C4)-alkyl, phenyl, benzyl or phenylethyl, B represents (C1-C7)-alkylene which is unsubstituted or substituted one or more times by hydroxyl, (C1-C4)-alkyl or by the group NR4R5 and which can optionally be closed to form an alicyclic 4- to 7-membered ring, R8 and R9, which can be identical or different, represent hydrogen or (C1-C6)-alkyl and Z represents phenyl, naphthyl, pyridyl or thiazolyl, each of which can be unsubstituted or substituted one or more times by (C1-C5)-alkyl, (C1-C5)-alkoxy, benzyloxy, tri- fluoromethyl, halogen, nitro, (C3-C7)-cycloalkoxy, (C1-C4)- alkylthio, trifluoromethylthio or by the group NR4R5, the pharmaceutically utilizable salts thereof, a process for the preparation thereof and the use thereof as medicament for the treatment of hypertension, cardiac insufficiency and disturbances of peripheral circulation.
Blaschke Heinz
Enzenhofer Rita
Fellier Harald
Stroißnig Heimo
Hafslund Nycomed Pharma Aktiengesellschaft
Riches Mckenzie & Herbert Llp
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