Piperazinylpiperidine derivatives as chemokine receptor...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 401/14 (2006.01) A61K 31/506 (2006.01)

Patent

CA 2562235

The present invention relates to compounds of Formula (I): wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.

La présente invention concerne des composés représentés par la formule générale (I) dans laquelle les substituants variables sont définis dans la description. Ces composés modulent l'activité des récepteurs de chimiokines, tels que CCR5, ou se fixent à ces derniers. Dans certains modes de réalisation, les composés de l'invention sont sélectifs des CCR5. Les composés peuvent être utilisés, notamment, pour traiter des maladies associées à l'expression ou à l'activité des récepteurs de chimiokines, telles que des maladies inflammatoires, des maladies immunitaires et des infections virales.

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