C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/501 (2006.01) A61P 25/00 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2623160
The present invention relates to compounds that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
La présente invention concerne des composés qui sont des antagonistes à dissociation rapide du récepteur 2 de la dopamine. La présente invention concerne également des procédés de synthèse desdits composés et des préparations pharmaceutiques les comprenant au titre de principes actifs. Les composés peuvent être employés en tant que médicaments dans le traitement prophylactique ou thérapeutique de troubles du système nerveux central, par exemple la schizophrénie, en exerçant un effet antipsychotique sans effets secondaires sur la motricité.
de Bruyn Marcel Frans Leopold
Kennis Ludo Edmond Josephine
Langlois Xavier Jean Michel
Macdonald Gregor James
Van Den Keybus Frans Alfons Maria
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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