Piperidine and piperazine derivatives as inhibitors of the...

Details Piperidine and piperazine derivatives as inhibitors of the... Piperidine and piperazine derivatives as inhibitors of the...

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/435 (2006.01) A61P 25/28 (2006.01) C07D 221/08 (2006.01) C07D 401/14 (2006.01) C07D 451/08 (2006.01) C07D 457/02 (2006.01)

Patent

CA 2362389

A compound of formula (I) wherein X is (II) or (III) wherein R' is a group (a), R is a group (e) or (f) wherein n is 0 to 3. In particular the agents of the invention inhibit the formation of .beta.-amyloid (A.beta.) peptide into neurotoxic fibrils, thereby acting to prevent or slow down the accumulation of amyloid protein deposits in the brain.

L'invention porte sur un composé de formule (I) dans laquelle X est (II) ou (III) où R' est un groupe (a), R est un groupe (e) ou (f), et n est zéro ou 3. Lesdits composés sont des inhibiteurs de la transformation du peptide .beta.-amyloïde (A.beta.) en fibrilles neurotoxiques, et agissent de ce fait pour prévenir ou ralentir la formation de dépôts de protéines amyloïdes dans le cerveau.

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