C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/254, 260/273
C07D 211/34 (2006.01) A61K 31/395 (2006.01) C07D 211/22 (2006.01) C07D 211/26 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)
Patent
CA 1279317
Abstract of the Disclosure A novel piperidine derivative is defined by the formula (I), including a salt thereof, Image (I) wherein R1 denotes a univalent group derived from one selected among substituted or unsubstituted benzene, pyridine, pyrazine, indole, anthraquinone, quinoline, substituted or unsubstituted phthalimide, homophthalimide, pyridinecarboxylic acid imide, pyridine N-oxide, pyrazinedicarboxylic acid imide, naphthalenedicarboxylic acid imide, substituted or unsubstituted quinazolinedione, 1,8-naphthalimide, bicyclo [2.2.2] oct-5-ene-2,3-dicarboxylic acid imide and pyromeryiimide, X denotes a group of the formula -(CH2)n-, a group of the formula -O(CH2)n-, a group of the formula -S(CH2)n-, a group of the formula -NH(CH2)n-, a group of the formula. -SO2NH(CH2)n-, a group of the formula Image , a group of the formula Image , a group of the formula Image , a group of the formula -CH2NH(CH2)n-, a group of the formula Image (in all the above formulas, n is an integer of 1 through 7 and R3 represents a lower alkyl group or a benzyl group), a group of the formula Image , a group of the formula Image , a group of the formula -O-CH2CH2CH= or a group of the formula Image , the ring A denotes a group of the formula Image , a group of the formula Image , a group of the formula Image or a group of the formula Image , and R2 denotes a hydrogen atom, a lower alkyl group, a substituted or unsubstituted benzyl group, a substituted or unsubstituted benzoyl group, a pyridyl group, a 2- hydroxyethyl group, a pyridylmethyl group or a group of the formula Image (wherein Z represents a halogen atom) and is useful as medicine, particularly for treating dementias and sequelae of cerebrovascular diseases.
526282
Araki Shin
Higurashi Kunizou
Karibe Norio
Kubota Atsuhiko
Nakamura Takaharu
Eisai Co. Ltd.
Smart & Biggar
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