Piperidine derivative and pharmaceutical composition

C - Chemistry – Metallurgy – 07 – D

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C07D 211/34 (2006.01) A61K 31/395 (2006.01) C07D 211/22 (2006.01) C07D 211/26 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 1279317

Abstract of the Disclosure A novel piperidine derivative is defined by the formula (I), including a salt thereof, Image (I) wherein R1 denotes a univalent group derived from one selected among substituted or unsubstituted benzene, pyridine, pyrazine, indole, anthraquinone, quinoline, substituted or unsubstituted phthalimide, homophthalimide, pyridinecarboxylic acid imide, pyridine N-oxide, pyrazinedicarboxylic acid imide, naphthalenedicarboxylic acid imide, substituted or unsubstituted quinazolinedione, 1,8-naphthalimide, bicyclo [2.2.2] oct-5-ene-2,3-dicarboxylic acid imide and pyromeryiimide, X denotes a group of the formula -(CH2)n-, a group of the formula -O(CH2)n-, a group of the formula -S(CH2)n-, a group of the formula -NH(CH2)n-, a group of the formula. -SO2NH(CH2)n-, a group of the formula Image , a group of the formula Image , a group of the formula Image , a group of the formula -CH2NH(CH2)n-, a group of the formula Image (in all the above formulas, n is an integer of 1 through 7 and R3 represents a lower alkyl group or a benzyl group), a group of the formula Image , a group of the formula Image , a group of the formula -O-CH2CH2CH= or a group of the formula Image , the ring A denotes a group of the formula Image , a group of the formula Image , a group of the formula Image or a group of the formula Image , and R2 denotes a hydrogen atom, a lower alkyl group, a substituted or unsubstituted benzyl group, a substituted or unsubstituted benzoyl group, a pyridyl group, a 2- hydroxyethyl group, a pyridylmethyl group or a group of the formula Image (wherein Z represents a halogen atom) and is useful as medicine, particularly for treating dementias and sequelae of cerebrovascular diseases.

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