Piperidine derivative and pharmaceutical composition...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 211/64 (2006.01) A61K 31/451 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) A61P 1/16 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 19/04 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01) A61P 27/14 (2006.01) A61P 29/00 (

Patent

CA 2475498

A piperidine derivative of formula (I) (see formula I) (wherein all symbols are as described in the specification.) and an intermediate for the preparation thereof. The compound of formula (I) has phosphodiesterase 4 inhibitory activity, and it is useful for the prevention and/or treatment of inflammatory diseases, diabetic diseases, allergic diseases, autoimmune diseases, ocular diseases, osteoporosis, bone fracture, osteoarthritis, obesity, bulimia, depression, Parkinson's disease, dementia, ischemia-reperfusion injury, leukemia, acquired immunodeficiency deficiency syndrome (AIDS), shock, systemically inflammatory responsive diseases (SIRS), etc.

L'invention concerne des dérivés de pipéridine représentés par la formule générale (I) suivante (dont chaque symbole est défini dans le descriptif), et la production d'intermédiaires de ces dérivés : (I). En raison de leur activité inhibitrice de la phophodiestérase 4, les composés représentés par la formule générale (I) sont utiles pour la prévention et/ou le traitement des maladies inflammatoires, des pathologies diabétiques, des maladies allergiques, des maladies auto-immunes, des maladies oculaires, de l'ostéoporose, des fractures osseuses, de la polyarthrite rhumatoïde, de l'obésité, de l'hyperphagie, de la dépression, de la maladie de Parkinson, des démences, des lésions dues à la reperfusion ischémique, des leucémies, du syndrome d'immunodéficience acquis (SIDA), des états de choc, du syndrome de réponse inflammatoire systémique (SIRS) etc.

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