Piperidine derivative or pharmaceutically acceptable salt...

Details Piperidine derivative or pharmaceutically acceptable salt... Piperidine derivative or pharmaceutically acceptable salt...

C - Chemistry, Metallurgy

07

D

C07D 211/16 (2006.01) A61K 31/438 (2006.01) A61K 31/439 (2006.01) A61K 31/445 (2006.01) A61K 31/453 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61K 31/553 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 43/00 (2006.01) C07D 211/18 (2006.01) C07D 211/22 (2006.01) C07D 211/28 (2006.01) C07D 211/34 (2006.01) C07D 211/42 (2006.01) C07D 211/62 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 413

Patent

CA 2578604

A piperidine derivative in which the piperidine ring is bonded in the 4- position to a monosubstituted or unsubstituted (-R1) benzene ring through vinylene and has an acyl group (-C(=O)-R4) in the 1-position; or a pharmaceutically acceptable salt of the derivative. The derivative and salt are excellent in sodium channel inhibitory activity and analgetic activity and have a high analgetic effect especially on neurogenic pains. The compounds are useful as a sodium channel inhibitor reduced in side effects.

L'invention concerne un dérivé de pipéridine dans lequel le noyau pipéridine est lié en position 4 à un noyau benzène monosubstitué ou non substitué (-R1) par un vinylène et possède un groupe acyle (-C(=O)-R4) en position 1 ; ou un sel pharmaceutiquement acceptable du dérivé. Le dérivé et le sel sont excellents en terme d'activité d'inhibition du canal sodique et d'activité analgésique et présentent un puissant effet analgésique spécialement pour les douleurs neurogènes. Les composés sont utiles comme inhibiteurs du canal sodique présentant des effets secondaires limités.

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