C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 411/12 (2006.01) C07D 413/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2148700
2148700 9410174 PCTABS00032 Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof: X-CO-Y-Z, wherein X is a monocyclic or polycyclic aromatic group, Y is O or NH; Z is of sub-formula (II), wherein -(CH2)n1 is attached at carbon; and n1 is 0, 1, 2, 3 or 4; q is 0, 1, 2 or 3; Ra is straight or branched chain alkylene of chain length 1-6 carbon atoms terminally substituted by R7 wherein R7 is aryl, 3 to 8 membered cycloalkyl, 3 to 8 membered heterocyclyl, 5 or 6 membered monocyclic heteroaryl or 9 or 10 membered fused bicyclic heteroaryl linked through carbon, or R7 is C2-7 alkoxycarbonyl or secondary or tertiary hydroxy substituted C1-6 alkyl; and R6 is hydrogen or C1-6 alkyl; or a compound of formula (I) wherein the CO-Y linkage is replaced by a heterocyclic bioisostere; and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.
Gaster Laramie Mary
Wyman Paul Adrian
Gowling Lafleur Henderson Llp
Smithkline Beecham P.l.c.
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