Piperidine derivatives as melanocortin-4 receptor agonists

Details Piperidine derivatives as melanocortin-4 receptor agonists Piperidine derivatives as melanocortin-4 receptor agonists

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2532808

Certain novel piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

L'invention concerne de nouveaux dérivés de pipéridine utilisés en tant qu'agonistes du/des récepteur(s) de la mélanocortine humaine, en particulier en tant qu'agonistes sélectifs du récepteur de la mélanocortine humaine 4 (MC-4R). Les dérivés selon l'invention sont donc utiles dans le traitement, le contrôle ou la prévention de maladies et de troubles liés à l'activation du MC-4R, tels que l'obésité, le diabète, la dysfonction sexuelle, notamment la dysérection et la dysfonction sexuelle féminine.

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