Piperidine derivatives as subtype selective...

Details Piperidine derivatives as subtype selective... Piperidine derivatives as subtype selective...

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/454 (2006.01) A61P 9/00 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2436699

Described are piperlines of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) ar antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, stroke, cerebral ischemia, central nervous system disorders, depression, trauma, hypoglycemia, neurodegenerative disorders, anxiety, migraine headache, convulsions, Parkinson's disease, aminoglycoside antibiotics-induced hearing loss, psychosis, glaucoma, CMV retitins, opioid tolerance or withdrawal, pain, especially chronic pain, neuropathic pain, or surgical pain, or urinary incontinence.

L'invention concerne des pipéridines représentées par la formule (I), y compris les sels pharmaceutiquement acceptables correspondants. Il s'agit d'antagonistes vis-vis des complexes de canaux NMDA, utiles pour traiter les maladies vasculaires cérébrales suivantes: par exemple, accident vasculaire cérébral, ischémie cérébrale, troubles du système nerveux central, dépression, traumatisme, hypoglycémie, troubles neurodégénératifs, anxiété, migraine, convulsions, maladie de Parkinson, troubles de l'audition induits par des antibiotiques à base d'aminoglycoside, psychose, glaucome, rétinite à cytomégalovirus, tolérance ou syndrome de sevrage aux opiacés, douleur, en particulier douleur chronique, douleur neuropathique, ou bien douleur chirurgicale, ou bien encore incontinence d'urine.

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