Piperidine derivatives having ccr3 antagonism

Details Piperidine derivatives having ccr3 antagonism Piperidine derivatives having ccr3 antagonism

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61K 31/5415 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 31/18 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (

Patent

CA 2484261

It is intended to provide low-molecular weight compounds having an activity of inhibiting the binding of a CCR3 ligand to CCR3 on a target cell, i.e., CCR3 antagonists. Namely, compounds represented by the following general formula (I), pharmaceutically acceptable acid addition salts thereof or pharmaceutically acceptable C1-6 alkyl adducts thereof and medicinal compositions having effects of treating and/or preventing diseases in which CCR3 participates such as asthma and allergic nephritis which contain the same as the active ingredient.

L'invention porte sur des composés de faible poids moléculaire dont l'activité inhibe la liaison d'un ligand à CCR3 sur une cellule cible, c'est-à-dire des antagonistes de CCR3. L'invention porte notamment sur des composés de formule générale (I), leurs sels d'addition acides acceptables d'un point de vue pharmaceutique ou leurs produits d'addition alkyle C¿1-6 ?acceptables d'un point de vue pharmaceutique, et sur des compositions médicinales dont l'efficacité permet de traiter ou de prévenir des maladies dans lesquelles participe CCR3, telles que l'asthme et la néphrite allergique, ces compositions contenant comme ingrédients actifs les mêmes composés que ceux de formule (I).

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