Piperidine derivatives, their preparation and pharmaceutical...

Details Piperidine derivatives, their preparation and pharmaceutical... Piperidine derivatives, their preparation and pharmaceutical...

C - Chemistry, Metallurgy

07

D

260/254, 260/278

C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 1244027

- 16 - ABSTRACT "PIPERIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM" Piperidine derivatives which are compounds of formula (I) Image wherein Ar1 and Ar2 independently represent a phenyl group optionally substituted by a halogen atom, a thienyl group or a pyridinyl group, A represents an alkylene group of 2 to 6 carbon atoms, X represents a CO group or a bond, R1 represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, either R2 represents a hydrogen atom and R3 represents a hydrogen atom or a hydroxy group, or R2 and R3 together represent a bond, and R4 represents a hydrogen or halogen atom, or pharmaceutically acceptable acid addition salts thereof are useful as antiallergics and antipruritics.

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