Piperidine derivatives useful as ccr5 antagonists

Details Piperidine derivatives useful as ccr5 antagonists Piperidine derivatives useful as ccr5 antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61P 31/18 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2510027

The present invention provides a compound of the formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein the various moieties are as defined in the specification. The present invention also provides pharmaceutical compositions containing the compound of this invention, and methods of treatment using the compound of this invention. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.

La présente invention porte sur un composé de formule (I) ou sur un sel ou un solvate de celui-ci acceptable d'un point de vue pharmaceutique. Dans cette formule, les diverses fractions sont telles que définis dans le descriptif. La présente invention porte également sur des compositions pharmaceutiques contenant le composé de l'invention, et sur des procédés de traitement utilisant ledit composé. L'invention porte sur l'utilisation d'une combinaison d'un composé de cette invention et sur au moins un agent antiviral ou agents utiles dans le traitement du virus de l'immunodéficience humaine (VIH). L'invention porte encore sur l'utilisation d'un composé de cette invention, seul ou en combinaison avec un autre agent, dans le traitement du rejet de transplantation d'un organe solide, de la maladie du greffon contre l'hôte, l'arthrite, l'arthrite rhumatoïde, la maladie intestinale inflammatoire, la dermatite atopique, le psoriasis, l'asthme, les allergies ou la sclérose en plaques.

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