C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/58 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61P 3/00 (2006.01) C07D 241/20 (2006.01) C07D 295/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2664141
The present invention is concerned with novel piperidine or piperazine substituted tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
La présente invention concerne de nouveaux dérivés de l'acide tétrahydronaphtalène-1-carboxylique substitué par un groupe pipéridinyle ou pipérazinyle ayant une activité d'inhibition de la sécrétion de l'apoB/de la MTP et une activité hypolipidémiante concomitante. L'invention concerne en outre des procédés servant à préparer de tels composés, des compositions pharmaceutiques comprenant lesdits composés ainsi que l'utilisation desdits composés en tant que médicament pour le traitement de l'athérosclérose, de la pancréatite, de l'obésité, de l'hypertriglycéridémie, de l'hypercholestérolémie, de l'hyperlipidémie, du diabète et du diabète de type II.
Backx Leo Jacobus Jozef
Berthelot Didier Jean-Claude
Busscher Guuske Frederike
Jaroskova Libuse
Linders Joannes Theodorus Maria
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica Nv
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