Piperidinopyrimidine derivatives for topical application

Details Piperidinopyrimidine derivatives for topical application Piperidinopyrimidine derivatives for topical application

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 9/12 (2006.01) A61K 31/506 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61P 17/04 (2006.01) A61Q 7/00 (2006.01)

Patent

CA 2328950

A pharmaceutical composition for topical administration, including, as the pharmaceutically active component, at least 5 % by weight, based on the total weight of the composition of a piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; an acid in an amount to completely solubilise the piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; a solvent composition including at least two of water, a lower alcohol and a co-solvent selected from one or more of the group consisting of aromatic and polyhydric alcohols; wherein when the co-solvent includes propylene glycol, it is present in an amount of less than approximately 10 % by weight.

L'invention concerne une composition pharmaceutique pour administration topique, renfermant comme principe actif pharmaceutique: au moins 5 % en poids, sur la base du poids total de la composition, d'un dérivé de pipéridinopyrimidine, ou d'un sel pharmaceutiquement acceptable de celui-ci; une quantité d'un acide permettant de solubiliser entièrement ce dérivé de pipéridinopyrimidine ou le sel pharmaceutiquement acceptable de celui-ci; et une composition de solvant contenant au moins deux constituants parmi l'eau, un alcool inférieur, et un cosolvant, lesquels sont choisis dans le groupe composé par les alcools aromatiques et polyhydriques, de sorte que lorsque le cosolvant renferme du propylèneglycol, ce cosolvant est présent dans une proportion inférieure ou égale à 10 % en poids environ.

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