C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/435 (2006.01) A61K 31/436 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/506 (2006.01) A61P 25/00 (2006.01) C07D 295/12 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2521700
The invention relates to a compound having general formula (I), wherein: A = N or CR2; R2 = H, F, OH, CN, CF3, C1-6-alkyl, C1-6-alcoxy; n = 2 or 3 and m = 2 when A = N; n = 1, 2 or 3 and m = 1 or 2 when A = CR2; B = covalent bond or C1-8-alkylene; R1 = optionally-substituted heteroaryl; R3 = CHR4CONHR5; R4 = H or C1-6-alkyl; R5 = H, C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-Cl-6-alkylene; the base, the acid addition salt, the hydrate or the solvate thereof. The invention also relates to the application thereof in therapeutics.
Composé répondant à la formule générale (I) : dans laquelle A = N ou CR2 ; R2 = H, F, OH, CN, CF3, C1-6~-alkyle, C1-6-alcoxy ; n = 2 ou 3 et m = 2 lorsque A = N ; n = 1, 2 ou 3 et m = 1 ou 2 lorsque A = CR2 ; B = liaison covalente ou C1-8-alkylène ; R1 = hétéroaryle éventuellement substitué ; R3 = CHR4CONHR5 ; R4 = H ou C1-6-alkyle ; R5 = H, C1-6-alkyle, C3-7-cycloalkyle, C3-7- cycloalkyle-Cl-6-alkylène ; à l'état de base, de sel d'addition à un acide, d'hydrate ou de solvat. Application en thérapeutique.
Abouabdellah Ahmed
Burnier Philippe
Hoornaert Christian
Jeunesse Jean
Puech Frederic
Kirby Eades Gale Baker
Sanofi-Aventis
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