Piperidinyl benzimidazoles

Details Piperidinyl benzimidazoles Piperidinyl benzimidazoles

C - Chemistry, Metallurgy

07

D

167/231, 260/278

C07D 401/06 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2000468

The present invention is directed to a new class of piperidinyl benzimidazole derivatives of the formula: Image wherein Y is represented by CO or CHOH; m is an integer from 1 to 2; R is represented by C1-4 alkyl, C1-4 alkoxy, halogen, hydroxy and hydrogen; X is represented by hydrogen, COOR2 in which R2 is represented by a C1-4 alkyl, or X is an alkylene phenyl radical of the formula: Image wherein T is represented by CHOH, CO, O, or a direct bond; R1 is represented by C1-4 alkyl, C1-4 alkoxy, halogen, hydroxy, 2,2-dimethyl ethanoic acid and hydrogen; n is an integer from 1 to 5; and pharmaceutically acceptable acid addition salts thereof; which are useful as antihistamines.

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