C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/08 (2006.01) A61K 31/445 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2651987
The present application describes substituted piperidinyl modulators of MIP-1 or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using said modulators are disclosed.
La présente invention concerne des modulateurs de pipéridinyl substitués de MIP-1 ou de CCR-1 ou des stéréoisomères ou sels dérivés pharmaceutiquement acceptables. Sont en outre révélés des procédés de traitement et de prévention de maladies inflammatoires telles que l'asthme et des maladies allergiques, ainsi que des pathologies autoimmunitaires telles que l'arthrite rhumatoïde et le rejet de transplant en utilisant lesdits modulateurs.
Carter Percy H.
Cavallaro Cullen L.
Dodd Dharmpal S.
Duncia John V.
Gardner Daniel S.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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