Piperidinyl targeting compounds that selectively bind integrins

Details Piperidinyl targeting compounds that selectively bind integrins Piperidinyl targeting compounds that selectively bind integrins

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4523 (2006.01) A61P 13/12 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2556768

The present invention relates to the synthesis and biological application of piperidinoyl carboxylic acid integrin antagonists affinity moiety of Formula (I) and Formula (II). These affinity moieties may be used with imaging agents or liposomes to target cells that express the .alpha.v.beta.3, .alpha.v.beta.5, or .alpha.v.beta.6 integrin receptors. Wherein W, R2, Z and q are as described in the application.

L'invention concerne la synthèse et l'application biologique d'une fraction d'affinité d'antagonistes d'intégrine d'acide carboxylique pipéridinoyle représentée par les formules (I) et (II). Ces fractions d'affinité peuvent être utilisées avec des agents d'imagerie ou des liposomes afin de cibler des cellules qui expriment les récepteurs d'intégrine .alpha.¿v?.beta.¿3?, .alpha.¿v?.beta.¿5?, ou .alpha.v.beta.¿6?. Dans ces formules, W, R¿2?, Z et q sont tels que décrits dans l'application.

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