C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/501 (2006.01) A61P 25/18 (2006.01)
Patent
CA 2665924
The present invention relates to 6-(piperidin-4-ylamino)pyridazin-3-carbonitriles of formula (I) that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
La présente invention porte sur des 6-(pipéridin-4-ylamino)pyridazine-3-carbonitriles représentés par la formule (I) qui sont des antagonistes du récepteur 2 de la dopamine à dissociation rapide, sur des procédés pour préparer ces composés, sur des compositions pharmaceutiques comprenant ces composés en tant qu'ingrédient actif. Les composés trouvent une utilité en tant que médicaments pour traiter ou prévenir les troubles du système nerveux central, par exemple la schizophrénie, en exerçant un effet antipsychotique sans effets secondaires moteurs.
Andres-Gil Jose Ignacio
Bartolome-Nebreda Jose Manuel
Macdonald Gregor James
Van Den Keybus Frans Alfons Maria
Van Gool Michiel Luc Maria
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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