Piperidinylamino-thieno[2,3-d] pyrimidine compounds

Details Piperidinylamino-thieno[2,3-d] pyrimidine compounds Piperidinylamino-thieno[2,3-d] pyrimidine compounds

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/519 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2581175

The invention relates to 5-HT receptor modulators, particularly 5-HT2B antagonists. Novel piperidinylamino-thieno [2,3-d] pyrimidine compounds, and uses thereof for treating conditions including pulmonary arterial hypertension, congestive heart failure, hypertension, central nervous system disorders such as migraine, disorders of the gastrointestinal tract, restenosis, asthma, obstructive airway disease, prostatic hyperplasia and priapism, anxiety, depression, schizophrenia, neural injury and stroke. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also provided.

L'invention concerne des modulateurs de récepteurs 5-HT, en particulier des antagonistes du 5-HT2B. L'invention concerne de nouveaux composés pipéridinylamino-thiéno[2,3-d]pyrimidines et les utilisations de ceux-ci pour traiter des affections dont l'hypertension artérielle pulmonaire, l'insuffisance cardiaque congestive, l'hypertension, des troubles du système nerveux central tels que la migraine, des troubles du tractus gastro-intestinal, la resténose, l'asthme, un syndrome obstructif des voies respiratoires, l'hyperplasie de la prostate et le priapisme, l'anxiété, la dépression, la schizophrénie, une plaie neurale et l'accident cérébrovasculaire. L'invention concerne également des procédés de préparation et de nouveaux intermédiaires et des sels pharmaceutiques de ceux-ci.

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