Piperidinylpyrimidine derivatives

Details Piperidinylpyrimidine derivatives Piperidinylpyrimidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/535 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2250943

A compound of formula (1) wherein; X1 is amino or hydroxyl, X2 is carbonyl and the like, R1 is an alkyl, an aryl and the like, R2 is hydrogen and the like, and R3 is an alkyl and the like, or a pharmaceutical acceptable salt thereof, is effective for inhibiting the production and/or secretion of tumor necrosis factor in a patient in need of such inhibition.

L'invention concerne un composé de la formule (1) dans laquelle X?1¿ représente amino ou hydroxyle, X?2¿ représente carbonyle et analogue, R?1¿ représente un alkyle, un aryle et analogue, R?2¿ représente hydrogène et analogue, et R?3¿ représente un alykle et analogue, ou un sel pharmaceutiquement acceptable de ce composé, ce dernier étant efficace pour inhiber la production et/ou la sécrétion du facteur de nécrose tumorale chez un patient nécessitant cette inhibition.

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