Piperidone tachykinin antagonists

Details Piperidone tachykinin antagonists Piperidone tachykinin antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/445 (2006.01) C07D 211/76 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2240964

The present invention provides compounds of formula (I) and the pharmaceutically acceptable acid addition salts thereof, wherein X is a direct link or C1-C4 alkylene; and R is C3-C7 cycloalkyl optionally substituted by 1 or 2 substituents each independently selected from fluoro and C3-C7 cycloalkyl: with the proviso that X is not methylene when R is cyclopropyl, together with processes for the preparation of, intermediates used in the preparation of, compositions containing and uses of, such compounds. These compounds are useful as tachykinin antagonists.

La présente invention concerne des composés présentant la formule (I), et les sels d'addition d'acides pharmaceutiquement acceptables de ces derniers. Dans la formule, X est une liaison directe ou de l'alkylène C¿1?-C¿4?; et R est du cycloalkyle C¿3?-C¿7? éventuellement substitué par 1 ou 2 substituants, sélectionnés chacun parmi fluoro et cycloalkyle C¿3?-C¿7?; à condition que X ne soitpas du méthylène lorsque R est du cyclopropyle. L'invention concerne également les procédés de préparation d'intermédiaires utilisés dans la préparation des compositions contenant ces composés, et leur utilisation. Ces composés sont des antagonistes utiles de la tachykinine.

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