C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4545 (2006.01)
Patent
CA 2728616
The present invention comprises compounds of Formula I. wherein: R1, R', R3, R4, R5 and X are as defined in the specitication. fhe invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is uveitis, including acute, recurring or chronic uveitis. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formu-la I.
La présente invention concerne des composés de formule I, dans laquelle : R1, R2, R3, R4, R5 et X sont comme défini dans la spécification. Linvention concerne en outre un procédé de traitement ou damélioration dun syndrome, dun trouble ou dune maladie, où ledit syndrome, trouble ou maladie est luvéite, comprenant luvéite aiguë, récurrente ou chronique. Linvention concerne en outre un procédé dinhibition de lactivité CCR2 chez un mammifère par administration dune quantité thérapeutiquement efficace dau moins un composé de formule I.
Cai Chaozhong
Sui Zhihua
Janssen Pharmaceutica Nv
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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