Piperidyl-quinazoline derivatives as tyrosine kinase inhibitors

Details Piperidyl-quinazoline derivatives as tyrosine kinase inhibitors Piperidyl-quinazoline derivatives as tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/517 (2006.01)

Patent

CA 2533345

The invention concerns quinazoline derivatives of formula (I) wherein R1and R2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB, particularly EGF, receptor tyrosine kinases.

L'invention concerne des dérivées de quinazoline représentés par la formule (I), dans laquelle R?1 ¿et R?2¿ peuvent avoir une signification quelconque parmi celles définies dans le descriptif, des procédés permettant de préparer ces dérivés, des compositions pharmaceutiques contenant ces dérivés, et l'utilisation de ces dérivés pour la préparation d'un médicament utilisé comme agent antiprolifératif dans la prévention ou le traitement des tumeurs qui sont sensibles à l'inhibition des récepteurs tyrosine kinases erbB, en particulier du récepteur de l'EGF.

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